HIGHLIGHTED TOPIC Pulmonary Circulation and Hypoxia Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation
نویسندگان
چکیده
Masatoshi Imamura, Bao Luo, Jennifer Limbird, Andrea Vitello, Masahiko Oka, D. Dunbar Ivy, Ivan F. McMurtry, Chrystelle V. Garat, Michael B. Fallon, and Ethan P. Carter Cardiovascular-Pulmonary Research Laboratory, Department of Medicine, University of Colorado Health Sciences Center, Denver; Department of Internal Medicine and Liver Center, University of Alabama at Birmingham, Birmingham, Alabama; and Pediatric Heart Lung Center and Section of Pediatric Cardiology, Department of Pediatrics, University of Colorado Health Sciences Center and The Children’s Hospital, Denver, Colorado
منابع مشابه
Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation.
Biliary cirrhosis in the rat triggers intrapulmonary vasodilatation and gas-exchange abnormalities that characterize the hepatopulmonary syndrome. This vasodilatation correlates with increased levels of pulmonary microcirculatory endothelial NO synthase (eNOS) and hepatic and plasma endothelin-1 (ET-1). Importantly, during cirrhosis, the pulmonary vascular responses to acute hypoxia are blunted...
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We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 micrograms i.v. ANF, pulmonary arterial pressure fell significantly from 26.5 +/- 2 to...
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Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...
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Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced activity of K(+) channels. As Kv7 channels ...
متن کاملPulmonary Vasodilatory Action of Endogenous Atrial Natriuretic Factor in Rats With Hypoxic Pulmonary Hypertension
We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 ,ug i.v. ANF, pulmonary arterial pressure fell significantly from 26.5±2 to 21±2 mm Hg...
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